4-(Trifluoromethyl)phenol → HCID 22049114, compound

HRID 2087318Notes

Reaction equation

HRID 2087318 reaction equation
[OH:1][CH:2]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=1)[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([C:11]2[CH:12]=[C:13]([NH:17][C:18](=[O:22])[CH:19]([CH3:21])[CH3:20])[CH:14]=[CH:15][CH:16]=2)[CH2:7][CH2:6]1.[F:31][C:32]([F:41])([F:40])[C:33]1[CH:38]=[CH:37][C:36](O)=[CH:35][CH:34]=1>>[CH3:30][O:29][C:26]1[CH:25]=[CH:24][C:23]([CH:2]([O:1][C:36]2[CH:37]=[CH:38][C:33]([C:32]([F:41])([F:40])[F:31])=[CH:34][CH:35]=2)[CH2:3][CH2:4][N:5]2[CH2:10][CH2:9][CH:8]([C:11]3[CH:12]=[C:13]([NH:17][C:18](=[O:22])[CH:19]([CH3:21])[CH3:20])[CH:14]=[CH:15][CH:16]=3)[CH2:7][CH2:6]2)=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 678744-(Trifluoromethyl)phenolHCID 22049044HCID 22049044, compound

Product 1

HCID 22049114HCID 22049114, compound

Procedure

Prepared by Procedure A and Scheme AN using N-(3-{1-[3-hydroxy-3-(4-methoxyphenyl)propyl]-4-piperidinyl}phenyl)-2-methylpropanamide and 4-trifluoromethyphenol: ESMS m/e: 555.1 (M+H)+.

Sources & evidence

ORD record
ord-db19a6fc56e64c11ad9b1665a8003778
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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