2-methyl-N-[3-(4-piperidyl)phenyl]propanamide → N-{3-[1-({2-[(4-Cyanobenzyl)oxy]-1-naphthyl)methyl)-4-piperidinyl]phenyl}-2-methylpropanamide

HRID 2087329Notes

Reaction equation

HRID 2087329 reaction equation
[CH:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[O:13][CH2:14][C:15]1[CH:22]=[CH:21][C:18]([C:19]#[N:20])=[CH:17][CH:16]=1)=O.[CH3:23][CH:24]([CH3:40])[C:25]([NH:27][C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([CH:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)[CH:29]=1)=[O:26]>>[C:19]([C:18]1[CH:17]=[CH:16][C:15]([CH2:14][O:13][C:4]2[CH:5]=[CH:6][C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[C:3]=2[CH2:1][N:37]2[CH2:38][CH2:39][CH:34]([C:30]3[CH:29]=[C:28]([NH:27][C:25](=[O:26])[CH:24]([CH3:40])[CH3:23])[CH:33]=[CH:32][CH:31]=3)[CH2:35][CH2:36]2)=[CH:22][CH:21]=1)#[N:20]

Participants

3

Reactant 2

HCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamideHCID 176086874-{[(1-Formyl-2-naphthyl)oxy]methyl}benzonitrile

Product 1

HCID 22049331N-{3-[1-({2-[(4-Cyanobenzyl)oxy]-1-naphthyl)methyl)-4-piperidinyl]phenyl}-2-methylpropanamide

Procedure

Prepared by Procedure F and Scheme R using 4-{[(1-formyl-2-naphthyl)oxy]methyl}benzonitrile and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 518.2 (M+H)+.

Workup

  1. customPrepared by Procedure F and Scheme R

Sources & evidence

ORD record
ord-6390ce7be91c42da8417c936a8a22294
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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