2-methyl-N-[3-(4-piperidyl)phenyl]propanamide → N-[3-(1-([2-(Cyanomethoxy)-1-naphthyl]methyl}-4-piperidinyl)phenyl]-2-methylpropanamide

HRID 2087331Notes

Reaction equation

HRID 2087331 reaction equation
[CH:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[O:13][CH2:14][C:15]#[N:16])=O.[CH3:17][CH:18]([CH3:34])[C:19]([NH:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:23]=1)=[O:20]>>[C:15]([CH2:14][O:13][C:4]1[CH:5]=[CH:6][C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:1][N:31]1[CH2:32][CH2:33][CH:28]([C:24]2[CH:23]=[C:22]([NH:21][C:19](=[O:20])[CH:18]([CH3:17])[CH3:34])[CH:27]=[CH:26][CH:25]=2)[CH2:29][CH2:30]1)#[N:16]

Participants

3

Reactant 2

HCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamideHCID 22049283[(1-Formyl-2-naphthyl)oxy]acetonitrile

Product 1

HCID 22049265N-[3-(1-([2-(Cyanomethoxy)-1-naphthyl]methyl}-4-piperidinyl)phenyl]-2-methylpropanamide

Procedure

Prepared by Procedure F and Scheme R using [(1-formyl-2-naphthyl)oxy]acetonitrile and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 442.2 (M+H)+.

Workup

  1. customPrepared by Procedure F and Scheme R

Sources & evidence

ORD record
ord-dcfe6bf9009244a9ac6f00a9afd07688
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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