2,3-Dihydrobenzofuran-5-carboxaldehyde → N-{3-[1-(2,3-Dihydro-1-benzofuran-5-ylmethyl)-4-piperidinyl]phenyl}-2-methylpropanamide

HRID 2087372Notes

Reaction equation

HRID 2087372 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]=O)=[CH:9][C:4]=2[CH2:3][CH2:2]1.[CH3:12][CH:13]([CH3:29])[C:14]([NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([CH:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[CH:18]=1)=[O:15]>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][N:26]3[CH2:27][CH2:28][CH:23]([C:19]4[CH:18]=[C:17]([NH:16][C:14](=[O:15])[CH:13]([CH3:12])[CH3:29])[CH:22]=[CH:21][CH:20]=4)[CH2:24][CH2:25]3)=[CH:9][C:4]=2[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 7359012,3-Dihydrobenzofuran-5-carboxaldehydeHCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamide

Product 1

HCID 22049578N-{3-[1-(2,3-Dihydro-1-benzofuran-5-ylmethyl)-4-piperidinyl]phenyl}-2-methylpropanamide

Procedure

Prepared by Procedure F and Scheme R using 2,3-dihydro-1-benzofuran-5-carbaldehyde and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 379.1 (M+H)+.

Workup

  1. customPrepared by Procedure F and Scheme R

Sources & evidence

ORD record
ord-2265ba8e77d64bc59e862453a299b70f
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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