1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene) → N-(6-{1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl}-2-pyridinyl)-2-methylpropanamide

HRID 2087410Notes

Reaction equation

HRID 2087410 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH:5]([C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)[C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1.[CH3:20][CH:21]([CH3:37])[C:22]([NH:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)[N:26]=1)=[O:23]>>[F:12][C:9]1[CH:10]=[CH:11][C:6]([CH:5]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH2:4][CH2:3][CH2:2][N:34]2[CH2:35][CH2:36][CH:31]([C:27]3[N:26]=[C:25]([NH:24][C:22](=[O:23])[CH:21]([CH3:20])[CH3:37])[CH:30]=[CH:29][CH:28]=3)[CH2:32][CH2:33]2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 768201,1'-(4-Chlorobutylidene)bis(4-fluorobenzene)HCID 22048748Propanamide, 2-methyl-N-[6-(4-piperidinyl)-2-pyridinyl]-

Product 1

HCID 22049284N-(6-{1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl}-2-pyridinyl)-2-methylpropanamide

Procedure

Prepared by Procedure G and Scheme AI using 1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene and 2-methyl-N-[6-(4-piperidinyl)-2-pyridinyl]propanamide: ESMS m/e: 492.2 (M+H)+.

Workup

  1. customPrepared by Procedure G and Scheme AI

Sources & evidence

ORD record
ord-024ae1de16e24696b2e9d6b5cb1647b8
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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