4-(3,4-Difluorophenoxy)benzaldehyde → N-(6-{1-[4-(3,4-Difluorophenoxy)benzyl]-4-piperidinyl}-2-pyridinyl)-2-methylpropanamide

HRID 2087411Notes

Reaction equation

HRID 2087411 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[F:17])[O:5][C:6]1[CH:13]=[CH:12][C:9]([CH:10]=O)=[CH:8][CH:7]=1.[CH3:18][CH:19]([CH3:35])[C:20]([NH:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)[N:24]=1)=[O:21]>>[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[F:17])[O:5][C:6]1[CH:13]=[CH:12][C:9]([CH2:10][N:32]2[CH2:33][CH2:34][CH:29]([C:25]3[N:24]=[C:23]([NH:22][C:20](=[O:21])[CH:19]([CH3:18])[CH3:35])[CH:28]=[CH:27][CH:26]=3)[CH2:30][CH2:31]2)=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 105857414-(3,4-Difluorophenoxy)benzaldehydeHCID 22048748Propanamide, 2-methyl-N-[6-(4-piperidinyl)-2-pyridinyl]-

Product 1

HCID 22048777N-(6-{1-[4-(3,4-Difluorophenoxy)benzyl]-4-piperidinyl}-2-pyridinyl)-2-methylpropanamide

Procedure

Prepared by Procedure AA and Scheme AJ using 4-(3,4-difluorophenoxy)benzaldehyde and 2-methyl-N-[6-(4-piperidinyl)-2-pyridinyl]propanamide: ESMS m/e: 466.0 (M+H)+.

Workup

  1. customPrepared by Procedure AA and Scheme AJ

Sources & evidence

ORD record
ord-1f6f380059e54a1ab70a002650c80a0e
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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