3-Chloro-1-propanol → N-{3-[1-(3-Hydroxypropyl)-4-piperidinyl]phenyl}-2-methylpropanamide

HRID 2087433Notes

Reaction equation

HRID 2087433 reaction equation
Cl[CH2:2][CH2:3][CH2:4][OH:5].[CH3:6][CH:7]([CH3:23])[C:8]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)[CH:12]=1)=[O:9]>>[OH:5][CH2:4][CH2:3][CH2:2][N:20]1[CH2:21][CH2:22][CH:17]([C:13]2[CH:12]=[C:11]([NH:10][C:8](=[O:9])[CH:7]([CH3:6])[CH3:23])[CH:16]=[CH:15][CH:14]=2)[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 123133-Chloro-1-propanolHCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamide

Product 1

HCID 22048877N-{3-[1-(3-Hydroxypropyl)-4-piperidinyl]phenyl}-2-methylpropanamide

Procedure

Prepared by Procedure G and Scheme B1 using 3-chloro-1-propanol and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 305.3 (M+H)+.

Workup

  1. customPrepared by Procedure G and Scheme B1

Sources & evidence

ORD record
ord-9399f1fbd1b44aa3ae6949e4ac6ccbb3
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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