5-Methyl-3-phenylisoxazole-4-carbonyl chloride → 4-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}butyl 5-methyl-3-phenyl-4-isoxazolecarboxylate

HRID 2087449Notes

Reaction equation

HRID 2087449 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[CH:13]=[C:14]([NH:18][C:19](=[O:23])[CH:20]([CH3:22])[CH3:21])[CH:15]=[CH:16][CH:17]=2)[CH2:8][CH2:7]1.[CH3:24][C:25]1[O:29][N:28]=[C:27]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:26]=1[C:36](Cl)=[O:37]>>[CH3:24][C:25]1[O:29][N:28]=[C:27]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:26]=1[C:36]([O:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][CH:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([NH:18][C:19](=[O:23])[CH:20]([CH3:21])[CH3:22])[CH:13]=2)[CH2:10][CH2:11]1)=[O:37]

Participants

3

Reactant 2

HCID 856245-Methyl-3-phenylisoxazole-4-carbonyl chlorideHCID 22048659N-(3-[1-(4-hydroxybutyl)-4-piperidinyl]phenyl}-2-methylpropanamide

Product 1

HCID 220486394-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}butyl 5-methyl-3-phenyl-4-isoxazolecarboxylate

Procedure

Prepared by Procedure Q1 and Scheme C2 (TEA) using N-{3-[1-(4-hydroxybutyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 5-methyl-3-phenyl-4-isoxazolecarbonyl chloride: ESMS m/e: 504.3 (M+H)+.

Workup

  1. customPrepared by Procedure Q1 and Scheme C2 (TEA)

Sources & evidence

ORD record
ord-a23a8b592888435aab4ec8339bd99794
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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