Benzo(b)thiophene-3-carbonyl chloride → N-(3-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}propyl)-1-benzothiophene-3-carboxamide

HRID 2087481Notes

Reaction equation

HRID 2087481 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([C:11]2[CH:12]=[C:13]([NH:17][C:18](=[O:22])[CH:19]([CH3:21])[CH3:20])[CH:14]=[CH:15][CH:16]=2)[CH2:7][CH2:6]1.[S:23]1[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=2[C:25]([C:32](Cl)=[O:33])=[CH:24]1>>[C:18]([NH:17][C:13]1[CH:12]=[C:11]([CH:8]2[CH2:9][CH2:10][N:5]([CH2:4][CH2:3][CH2:2][NH:1][C:32]([C:25]3[C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=4[S:23][CH:24]=3)=[O:33])[CH2:6][CH2:7]2)[CH:16]=[CH:15][CH:14]=1)(=[O:22])[CH:19]([CH3:20])[CH3:21]

Participants

3

Reactant 2

HCID 2776338Benzo(b)thiophene-3-carbonyl chlorideHCID 16757470N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}2-methylpropanamide

Product 1

HCID 20723050N-(3-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}propyl)-1-benzothiophene-3-carboxamide

Procedure

Prepared by Procedure Q1 and Scheme AC using N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 1-benzothiophene-3-carbonyl chloride: ESMS m/e: 464.2 (M+H)+.

Workup

  1. customPrepared by Procedure Q1 and Scheme AC

Sources & evidence

ORD record
ord-04ee3cde50c04dd0b84f3bb17394c3aa
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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