4-Fluorophenol → 1-{[(2R)-3-Chloro-2-methylpropyl]oxy}-4-fluorobenzene

HRID 2087499Notes

Reaction equation

HRID 2087499 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Br[CH2:10][C@@H:11]([CH3:14])[CH2:12][Cl:13]>>[Cl:13][CH2:12][C@H:11]([CH3:14])[CH2:10][O:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 97324-FluorophenolHCID 5479122(2S)-1-bromo-3-chloro-2-methylpropane

Product 1

HCID 695245761-{[(2R)-3-Chloro-2-methylpropyl]oxy}-4-fluorobenzene

Procedure

Prepared by Procedure U and Scheme AK using 4-fluorophenol and (2S)-1-bromo-3-chloro-2-methylpropane.

Workup

  1. customPrepared by Procedure U and Scheme AK

Sources & evidence

ORD record
ord-abe6b71e3cec4954bee67420e03a6c22
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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