4-Fluorophenol → HCID 58651295, compound

HRID 2087529Notes

Reaction equation

HRID 2087529 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.O[C@@H:10]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:11][N:12]1[CH2:17][CH2:16][CH:15]([C:18]2[CH:19]=[C:20]([NH:24][C:25](=[O:29])[CH:26]([CH3:28])[CH3:27])[CH:21]=[CH:22][CH:23]=2)[CH2:14][CH2:13]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C@H:10]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([C:18]3[CH:19]=[C:20]([NH:24][C:25](=[O:29])[CH:26]([CH3:28])[CH3:27])[CH:21]=[CH:22][CH:23]=3)[CH2:14][CH2:13]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 97324-FluorophenolHCID 69523634HCID 69523634, compound

Product 1

HCID 58651295HCID 58651295, compound

Procedure

Prepared by Procedure B and Scheme B1 using 4-fluorophenol and N-(3-{1-[(2S)-2-hydroxy-2-phenylethyl]-4-piperidinyl}phenyl)-2-methylpropanamide: ESMS m/e: 461.2 (M+H)+.

Workup

  1. customPrepared by Procedure B and Scheme B1

Sources & evidence

ORD record
ord-f19bfa7829cd4f939b385992df80ab34
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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