3-Bromopropionaldehyde dimethylacetal → N-{3-[1-(3,3-dimethoxypropyl)-4-piperidinyl]phenyl}-2-methylpropanamide

HRID 2087532Notes

Reaction equation

HRID 2087532 reaction equation
Br[CH2:2][CH2:3][CH:4]([O:7][CH3:8])[O:5][CH3:6].[CH3:9][CH:10]([CH3:26])[C:11]([NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH:15]=1)=[O:12]>>[CH3:6][O:5][CH:4]([O:7][CH3:8])[CH2:3][CH2:2][N:23]1[CH2:24][CH2:25][CH:20]([C:16]2[CH:15]=[C:14]([NH:13][C:11](=[O:12])[CH:10]([CH3:9])[CH3:26])[CH:19]=[CH:18][CH:17]=2)[CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 1189323-Bromopropionaldehyde dimethylacetalHCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamide

Product 1

HCID 22049337N-{3-[1-(3,3-dimethoxypropyl)-4-piperidinyl]phenyl}-2-methylpropanamide

Procedure

Prepared by Procedure G and Scheme B1 using 3-bromo-1,1-dimethoxypropane and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 349.2 (M+H)+.

Workup

  1. customPrepared by Procedure G and Scheme B1

Sources & evidence

ORD record
ord-ace52f5f28a6448fa2e654d19cea90ee
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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