Methyl iodide → N-(3-{1-[(3R)-3-(3,4-Dimethoxyphenoxy)-3-phenylpropyl]-4-piperidinyl}phenyl)-N,2-dimethylpropanamide

HRID 2087546Notes

Reaction equation

HRID 2087546 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:34]=[CH:35][C:36]=1[O:37][CH3:38])[O:6][C@@H:7]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][CH:13]([C:16]2[CH:17]=[C:18]([NH:22][C:23](=[O:27])[CH:24]([CH3:26])[CH3:25])[CH:19]=[CH:20][CH:21]=2)[CH2:12][CH2:11]1.[CH3:39]I>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:34]=[CH:35][C:36]=1[O:37][CH3:38])[O:6][C@@H:7]([C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][CH:13]([C:16]2[CH:17]=[C:18]([N:22]([CH3:39])[C:23](=[O:27])[CH:24]([CH3:26])[CH3:25])[CH:19]=[CH:20][CH:21]=2)[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 10279479N-(3-{1-[(3R)-3-(3,4-Dimethoxyphenoxy)-3-Phenylpropyl]-4-Piperidinyl}Phenyl)-2-Methylpropanamide

Product 1

HCID 58651333N-(3-{1-[(3R)-3-(3,4-Dimethoxyphenoxy)-3-phenylpropyl]-4-piperidinyl}phenyl)-N,2-dimethylpropanamide

Procedure

Prepared by Procedure T and Scheme AD using N-(3-{1-[(3R)-3-(3,4-dimethoxyphenoxy)-3-phenylpropyl]-4-piperidinyl}phenyl)-2-methylpropanamide and methyl iodide: ESMS m/e: 531.2 (M+H)+.

Workup

  1. customPrepared by Procedure T and Scheme AD

Sources & evidence

ORD record
ord-e98dcaf4ede842c280228afa9709123c
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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