N-[3-(4-Piperidinyl)phenyl]cyclopropanecarboxamide → N-(3-{1-[5-(3-Acetylphenoxy)pentyl]-4-piperidinyl}phenyl)cyclopropanecarboxamide

HRID 2087575Notes

Reaction equation

HRID 2087575 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:9]=[C:10]([C:14](=[O:16])[CH3:15])[CH:11]=[CH:12][CH:13]=1.[NH:17]1[CH2:22][CH2:21][CH:20]([C:23]2[CH:24]=[C:25]([NH:29][C:30]([CH:32]3[CH2:34][CH2:33]3)=[O:31])[CH:26]=[CH:27][CH:28]=2)[CH2:19][CH2:18]1>>[C:14]([C:10]1[CH:9]=[C:8]([CH:13]=[CH:12][CH:11]=1)[O:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][N:17]1[CH2:22][CH2:21][CH:20]([C:23]2[CH:24]=[C:25]([NH:29][C:30]([CH:32]3[CH2:33][CH2:34]3)=[O:31])[CH:26]=[CH:27][CH:28]=2)[CH2:19][CH2:18]1)(=[O:16])[CH3:15]

Participants

3

Reactant 2

HCID 22048669N-[3-(4-Piperidinyl)phenyl]cyclopropanecarboxamideHCID 220487861-{3-[(5-Chloropentyl)oxy]phenyl)ethanone

Product 1

HCID 22048597N-(3-{1-[5-(3-Acetylphenoxy)pentyl]-4-piperidinyl}phenyl)cyclopropanecarboxamide

Procedure

Prepared by Procedure G and Scheme B1 using 1-{3-[(5-chloropentyl)oxy]phenyl}ethanone and N-[3-(4-piperidinyl)phenyl]cyclopropanecarboxamide: ESMS m/e: 449.2 (M+H)+.

Workup

  1. customPrepared by Procedure G and Scheme B1

Sources & evidence

ORD record
ord-83fefa5bfa8c4a8592f5fdfa7434e654
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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