4-(Trifluoromethoxy)phenylhydrazine hydrochloride → 2-Methyl-N-[3-(1-{4-[2-phenyl-5-(trifluoromethoxy)-1H-indol-3-YL]butyl}-4-piperidinyl)phenyl]propanamide

HRID 2087583Notes

Reaction equation

HRID 2087583 reaction equation
[CH3:1][CH:2]([CH3:31])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23](=O)[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:14][CH2:13]2)[CH:7]=1)=[O:4].Cl.[F:33][C:34]([F:45])([F:44])[O:35][C:36]1[CH:41]=[CH:40][C:39]([NH:42]N)=[CH:38][CH:37]=1>>[CH3:1][CH:2]([CH3:31])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:13][CH2:14][N:15]([CH2:18][CH2:19][CH2:20][CH2:21][C:22]3[C:40]4[C:39](=[CH:38][CH:37]=[C:36]([O:35][C:34]([F:45])([F:44])[F:33])[CH:41]=4)[NH:42][C:23]=3[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:16][CH2:17]2)[CH:7]=1)=[O:4]

Participants

3

Reactant 2

HCID 27773284-(Trifluoromethoxy)phenylhydrazine hydrochlorideHCID 220488102-methyl-N-(3-[1-(6-oxo-6-phenylhexyl)-4-piperidinyl]phenyl}propanamide

Product 1

HCID 220486362-Methyl-N-[3-(1-{4-[2-phenyl-5-(trifluoromethoxy)-1H-indol-3-YL]butyl}-4-piperidinyl)phenyl]propanamide

Procedure

Prepared by Procedure E and Scheme M using 2-methyl-N-{3-[1-(6-oxo-6-phenylhexyl)-4-piperidinyl]phenyl}propanamide and 1-[4-(trifluoromethoxy)phenyl]hydrazine hydrochloride: ESMS m/e: 578.2 (M+H)+.

Workup

  1. customPrepared by Procedure E and Scheme M

Sources & evidence

ORD record
ord-16bf904c52e74f62bd0781fe808425fd
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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