Hydrazine, 1,1-diphenyl-, hydrochloride (1:1) → N-(3-{1-[4-(1,2-Diphenyl-1H-indol-3-YL)butyl]-4-piperidinyl}phenyl)-2-methylpropanamide

HRID 2087585Notes

Reaction equation

HRID 2087585 reaction equation
[CH3:1][CH:2]([CH3:31])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23](=O)[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:14][CH2:13]2)[CH:7]=1)=[O:4].Cl.[C:33]1([N:39]([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)N)[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[C:33]1([N:39]2[C:41]3[C:46](=[CH:45][CH:44]=[CH:43][CH:42]=3)[C:22]([CH2:21][CH2:20][CH2:19][CH2:18][N:15]3[CH2:16][CH2:17][CH:12]([C:8]4[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH:2]([CH3:31])[CH3:1])[CH:11]=[CH:10][CH:9]=4)[CH2:13][CH2:14]3)=[C:23]2[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

Participants

3

Reactant 2

HCID 10738Hydrazine, 1,1-diphenyl-, hydrochloride (1:1)HCID 220488102-methyl-N-(3-[1-(6-oxo-6-phenylhexyl)-4-piperidinyl]phenyl}propanamide

Product 1

HCID 22049062N-(3-{1-[4-(1,2-Diphenyl-1H-indol-3-YL)butyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Procedure

Prepared by Procedure E and Scheme M using 2-methyl-N-{3-[1-(6-oxo-6-phenylhexyl)-4-piperidinyl]phenyl}propanamide and 1,1-diphenylhydrazine hydrochloride: ESMS m/e: (M+H)+. 570.3.

Workup

  1. customPrepared by Procedure E and Scheme M

Sources & evidence

ORD record
ord-f16348464c54490daecc352be3a3ff90
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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