Hydrazine, 1-naphthalenyl-, hydrochloride (1:1) → 2-Methyl-N-(3-{1-[4-(2-phenyl-1H-benzo[G]indol-3-YL)butyl]-4-piperidinyl}phenyl)propanamide

HRID 2087589Notes

Reaction equation

HRID 2087589 reaction equation
[CH3:1][CH:2]([CH3:31])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23](=O)[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:14][CH2:13]2)[CH:7]=1)=[O:4].Cl.[C:33]1([NH:43]N)[C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH:36]=[CH:35][CH:34]=1>>[CH3:1][CH:2]([CH3:31])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][CH2:21][C:22]3[C:34]4[C:33](=[C:42]5[CH:41]=[CH:40][CH:39]=[CH:38][C:37]5=[CH:36][CH:35]=4)[NH:43][C:23]=3[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:14][CH2:13]2)[CH:7]=1)=[O:4]

Participants

3

Reactant 2

HCID 519949Hydrazine, 1-naphthalenyl-, hydrochloride (1:1)HCID 220488102-methyl-N-(3-[1-(6-oxo-6-phenylhexyl)-4-piperidinyl]phenyl}propanamide

Product 1

HCID 220487012-Methyl-N-(3-{1-[4-(2-phenyl-1H-benzo[G]indol-3-YL)butyl]-4-piperidinyl}phenyl)propanamide

Procedure

Prepared by Procedure E and Scheme M using 2-methyl-N-{3-[1-(6-oxo-6-phenylhexyl)-4-piperidinyl]phenyl}propanamide and 1-(1-naphthyl)hydrazine hydrochloride: ESMS m/e: 544.3 (M+H)+.

Workup

  1. customPrepared by Procedure E and Scheme M

Sources & evidence

ORD record
ord-6c78ba21fd69409ba26b626e018ded98
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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