4-Chloro-4'-isopropylbutyrophenone → N-(3-{1-[4-(4-Isopropylphenyl)-4-oxobutyl]-4-piperidinyl}phenyl)cyclopropanecarboxamide

HRID 2087680Notes

Reaction equation

HRID 2087680 reaction equation
Cl[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([CH:13]([CH3:15])[CH3:14])=[CH:9][CH:8]=1)=[O:6].[NH:16]1[CH2:21][CH2:20][CH:19]([C:22]2[CH:23]=[C:24]([NH:28][C:29]([CH:31]3[CH2:33][CH2:32]3)=[O:30])[CH:25]=[CH:26][CH:27]=2)[CH2:18][CH2:17]1>>[CH:13]([C:10]1[CH:11]=[CH:12][C:7]([C:5](=[O:6])[CH2:4][CH2:3][CH2:2][N:16]2[CH2:21][CH2:20][CH:19]([C:22]3[CH:23]=[C:24]([NH:28][C:29]([CH:31]4[CH2:32][CH2:33]4)=[O:30])[CH:25]=[CH:26][CH:27]=3)[CH2:18][CH2:17]2)=[CH:8][CH:9]=1)([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 987444-Chloro-4'-isopropylbutyrophenoneHCID 22048669N-[3-(4-Piperidinyl)phenyl]cyclopropanecarboxamide

Product 1

HCID 22049513N-(3-{1-[4-(4-Isopropylphenyl)-4-oxobutyl]-4-piperidinyl}phenyl)cyclopropanecarboxamide

Procedure

Prepared by Procedure K and Scheme B1 using 4-chloro-1-(4-isopropylphenyl)-1-butanone and N-[3-(4-piperidinyl) phenyl]cyclopropanecarboxamide: ESMS m/e: 433.2 (M+H)+.

Workup

  1. customPrepared by Procedure K and Scheme B1

Sources & evidence

ORD record
ord-c814dc01f2e0420395d41c2042b8cc65
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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