4-Phenoxyphenyl isocyanate → HCID 58651328, compound

HRID 2087762Notes

Reaction equation

HRID 2087762 reaction equation
[N:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:6][CH:5]=1)=[C:2]=[O:3].[NH2:17][C@H:18]([C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)[CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][CH:24]([C:27]2[CH:28]=[C:29]([NH:33][C:34](=[O:38])[CH:35]([CH3:37])[CH3:36])[CH:30]=[CH:31][CH:32]=2)[CH2:23][CH2:22]1>>[CH3:36][CH:35]([CH3:37])[C:34]([NH:33][C:29]1[CH:30]=[CH:31][CH:32]=[C:27]([CH:24]2[CH2:23][CH2:22][N:21]([CH2:20][CH2:19][C@H:18]([NH:17][C:2]([NH:1][C:4]3[CH:9]=[CH:8][C:7]([O:10][C:11]4[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=4)=[CH:6][CH:5]=3)=[O:3])[C:39]3[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=3)[CH2:26][CH2:25]2)[CH:28]=1)=[O:38]

Participants

3

Reactant 2

HCID 27348964-Phenoxyphenyl isocyanateHCID 69523474N-(3-(1-[(3S)-3-amino-3-phenylpropyl]-4-piperidinyl)phenyl)-2-methylpropanamide

Product 1

HCID 58651328HCID 58651328, compound

Procedure

Prepared by Procedure P and Scheme AB using 1-isocyanato-4-phenoxybenzene and N-(3-{1-[(3S)-3-amino-3-phenylpropyl]-4-piperidinyl}phenyl)-2-methylpropanamide: ESMS m/e: 591.3 (M+H)+.

Workup

  1. customPrepared by Procedure P and Scheme AB

Sources & evidence

ORD record
ord-5137d3fff67f435ea70bfa8c66c50673
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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