tert-Butyl isothiocyanate → HCID 58651275, compound

HRID 2087764Notes

Reaction equation

HRID 2087764 reaction equation
[N:1]([C:4]([CH3:7])([CH3:6])[CH3:5])=[C:2]=[S:3].[NH2:8][C@H:9]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:10][CH2:11][N:12]1[CH2:17][CH2:16][CH:15]([C:18]2[CH:19]=[C:20]([NH:24][C:25](=[O:29])[CH:26]([CH3:28])[CH3:27])[CH:21]=[CH:22][CH:23]=2)[CH2:14][CH2:13]1>>[C:4]([NH:1][C:2]([NH:8][C@H:9]([C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)[CH2:10][CH2:11][N:12]1[CH2:17][CH2:16][CH:15]([C:18]2[CH:19]=[C:20]([NH:24][C:25](=[O:29])[CH:26]([CH3:28])[CH3:27])[CH:21]=[CH:22][CH:23]=2)[CH2:14][CH2:13]1)=[S:3])([CH3:7])([CH3:6])[CH3:5]

Participants

3

Reactant 2

HCID 11544tert-Butyl isothiocyanateHCID 69523474N-(3-(1-[(3S)-3-amino-3-phenylpropyl]-4-piperidinyl)phenyl)-2-methylpropanamide

Product 1

HCID 58651275HCID 58651275, compound

Procedure

Prepared by Procedure P and Scheme AB using 2-isothiocyanato-2-methylpropane and N-(3-{1-[(3S)-3-amino-3-phenylpropyl]-4-piperidinyl}phenyl)-2-methylpropanamide: ESMS m/e: 495.1 (M+H)+.

Workup

  1. customPrepared by Procedure P and Scheme AB

Sources & evidence

ORD record
ord-1bce9ee5c4b84ddd87042c697a83919a
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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