Phenyl isocyanate → N-[3-(1-{3-[(Anilinocarbonyl)amino]propyl}-4-piperidinyl)phenyl]-2-methylpropanamide

HRID 2087774Notes

Reaction equation

HRID 2087774 reaction equation
[N:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[C:2]=[O:3].[NH2:10][CH2:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][CH:17]([C:20]2[CH:21]=[C:22]([NH:26][C:27](=[O:31])[CH:28]([CH3:30])[CH3:29])[CH:23]=[CH:24][CH:25]=2)[CH2:16][CH2:15]1>>[NH:1]([C:2]([NH:10][CH2:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][CH:17]([C:20]2[CH:21]=[C:22]([NH:26][C:27](=[O:31])[CH:28]([CH3:29])[CH3:30])[CH:23]=[CH:24][CH:25]=2)[CH2:16][CH2:15]1)=[O:3])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 7672Phenyl isocyanateHCID 16757470N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}2-methylpropanamide

Product 1

HCID 22048881N-[3-(1-{3-[(Anilinocarbonyl)amino]propyl}-4-piperidinyl)phenyl]-2-methylpropanamide

Procedure

Prepared by Procedure P and Scheme AB using isocyanatobenzene and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}-2-methylpropanamide: ESMS m/e: 422.9 (M+H)+.

Workup

  1. customPrepared by Procedure P and Scheme AB

Sources & evidence

ORD record
ord-809115db262f457fab8aaca85c97112c
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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