N-{3-[1-(3-amino propyl)4-piperidinyl]phenyl}acetamide → N-(3-{4-[3-(Acetylamino)phenyl]-1-piperidinyl}propyl)-4-(3,4-difluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide

HRID 2087779Notes

Reaction equation

HRID 2087779 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([C:11]2[CH:12]=[C:13]([NH:17][C:18](=[O:20])[CH3:19])[CH:14]=[CH:15][CH:16]=2)[CH2:7][CH2:6]1.[F:21][C:22]1[CH:23]=[C:24]([CH:29]2[CH2:34][C:33](=[O:35])[NH:32][C:31]([CH3:36])=[C:30]2[C:37](O)=[O:38])[CH:25]=[CH:26][C:27]=1[F:28]>>[C:18]([NH:17][C:13]1[CH:12]=[C:11]([CH:8]2[CH2:9][CH2:10][N:5]([CH2:4][CH2:3][CH2:2][NH:1][C:37]([C:30]3[CH:29]([C:24]4[CH:25]=[CH:26][C:27]([F:28])=[C:22]([F:21])[CH:23]=4)[CH2:34][C:33](=[O:35])[NH:32][C:31]=3[CH3:36])=[O:38])[CH2:6][CH2:7]2)[CH:16]=[CH:15][CH:14]=1)(=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 21957249N-{3-[1-(3-amino propyl)4-piperidinyl]phenyl}acetamideHCID 220486704-(3,4-Difluorophenyl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-3-pyridinecarboxylic acid

Product 1

HCID 22725360N-(3-{4-[3-(Acetylamino)phenyl]-1-piperidinyl}propyl)-4-(3,4-difluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide

Procedure

Prepared by Procedure AC and Scheme AM using N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}acetamide and 4-(3,4-difluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylic acid: ESMS m/e: 525.2 (M+H)+.

Workup

  1. customPrepared by Procedure AC and Scheme

Sources & evidence

ORD record
ord-f236b729af274560803299e1bc19fc31
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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