Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2087837Generated: October 26, 2026

4-Isoxazolecarbonyl chloride, 3-(2-chlorophenyl)-5-methyl- → 3-(2-Chlorophenyl)-N-(5-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}pentyl)-5-methyl-4-isoxazolecarboxamide

https://huagongshe.com/reaction/2087837

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Isoxazolecarbonyl chloride, 3-(2-chlorophenyl)-5-methyl-HCID 96590—
ReactantN-{3-[1-(5-aminopentyl)-4-piperidinyl]phenyl}-2-methylpropanamideHCID 16755867—
SolventTetrahydrofurane dichloromethaneHCID 21919333—
Product3-(2-Chlorophenyl)-N-(5-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}pentyl)-5-methyl-4-isoxazolecarboxamideHCID 22049620—

Reaction Steps

Prepared by Procedure Q2 (THF/DCM, 1:3) and Scheme AT using N-{3-[1-(5-aminopentyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 3-(2-chlorophenyl)-5-methyl-4-isoxazolecarbonyl chloride: ESMS m/e: 551.0 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06727264B1
Source datasetuspto-grants-2004_04
ORD IDord-373f762694bc4365a2350b95fe76794f
Source noteuspto-grants-2004_04