Hydrazine, 1-naphthalenyl-, hydrochloride (1:1) → N-[3-(1-{3-[2-(3-Fluorophenyl)-1H-benzo[G]indol-3-YL]propyl}-4-piperidinyl)phenyl]-2-methylpropanamide

HRID 2087854Notes

Reaction equation

HRID 2087854 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8](=O)[CH2:9][CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][CH:16]([C:19]3[CH:20]=[C:21]([NH:25][C:26](=[O:30])[CH:27]([CH3:29])[CH3:28])[CH:22]=[CH:23][CH:24]=3)[CH2:15][CH2:14]2)[CH:5]=[CH:6][CH:7]=1.Cl.[C:33]1([NH:43]N)[C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH:36]=[CH:35][CH:34]=1>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:43][C:33]3[C:34]([C:9]=2[CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][CH:16]([C:19]4[CH:20]=[C:21]([NH:25][C:26](=[O:30])[CH:27]([CH3:29])[CH3:28])[CH:22]=[CH:23][CH:24]=4)[CH2:15][CH2:14]2)=[CH:35][CH:36]=[C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][C:42]=32)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 519949Hydrazine, 1-naphthalenyl-, hydrochloride (1:1)HCID 22049351N-(3-{1-[5-(3-Fluorophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Product 1

HCID 22049588N-[3-(1-{3-[2-(3-Fluorophenyl)-1H-benzo[G]indol-3-YL]propyl}-4-piperidinyl)phenyl]-2-methylpropanamide

Procedure

Prepared by Procedure E and Scheme M using N-(3-{1-[5-(3-fluorophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)-2-methylpropanamide and 1-naphthylhydrazine hydrochloride: ESMS m/e: 548.2 (M+H)+.

Workup

  1. customPrepared by Procedure E and Scheme M

Sources & evidence

ORD record
ord-5d97a6339a314912b2c2cf41e16cfd39
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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