HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(3-{1-[6-(4-Fluorophenoxy)-6-(4-fluorophenyl)hexyl]-4-piperidinyl}phenyl)-2-methylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Fluorophenol | HCID 9732 | — |
| Reactant | N-(3-(1-[6-(4-fluorophenyl)-6-hydroxyhexyl]-4-piperidinyl}phenyl)-2-methylpropanamide | HCID 22048674 | — |
| Product | N-(3-{1-[6-(4-Fluorophenoxy)-6-(4-fluorophenyl)hexyl]-4-piperidinyl}phenyl)-2-methylpropanamide | HCID 22049270 | — |
Reaction Steps
Prepared by Procedure A and Scheme AN using 4-fluorophenol and N-(3-{1-[6-(4-fluorophenyl)-6-hydroxyhexyl]-4-piperidinyl}phenyl)-2-methylpropanamide: 1H NMR (400 MHz, CDCl3), HCl salt δ 8.22 (s, br, 1H), 7.74-6.70 (m, 12H), 5.05-4.94 (m, 1H), 3.66-3.52 (m, br, 2H), 3.02-2.83 (m, br, 2H), 2.81-2.58 (m, br, 4H), 2.58-2.36 (m, br, 2H), 2.02-1.66 (m, br, 6H), 1.66-1.46 (m, br, 1H), 1.46-1.35 (m, br, 3H), 1.26 (d, 6H, J=6.0 Hz); ESMS m/e: 535.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06727264B1 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-5a6ab3c15ee743efa1ad5c284e158352 |
| Source note | uspto-grants-2004_04 |