HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(3-{1-[6-(4-Chlorophenyl)-6-(4-fluorophenoxy)hexyl]-4-piperidinyl}phenyl)-2-methylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Fluorophenol | HCID 9732 | — |
| Reactant | N-(3-{1-(6-(4-chlorophenyl)-6-hydroxyhexyl]-4-piperidinyl}phenyl)-2-methylpropanamide | HCID 22049304 | — |
| Product | N-(3-{1-[6-(4-Chlorophenyl)-6-(4-fluorophenoxy)hexyl]-4-piperidinyl}phenyl)-2-methylpropanamide | HCID 22049421 | — |
Reaction Steps
Prepared by Procedure A and Scheme AN using 4-fluorophenol and N-(3-{1-[6-(4-chlorophenyl)-6-hydroxyhexyl]-4-piperidinyl}phenyl)-2-methylpropanamide: 1H NMR (400 MHz, CDCl3), HCl salt δ 8.22 (s, br, 1H), 7.74-6.68 (m, 12H), 5.04-4.92 (m, 1H), 3.66-3.50 (m, br, 2H), 3.00-2.82 (br, 2H), 2.80-2.58 (m, br, 4H), 2.58-2.40 (m, br, 2H), 2.00-1.68 (m, br, 6H), 1.66-1.46 (m, br, 1H), 1.46-1.36 (br, 3H), 1.25 (d, 6H, J=7.2 Hz); ESMS m/e: 551.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06727264B1 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-654c5547d4e0434dad2aacb9e4bac4ee |
| Source note | uspto-grants-2004_04 |