HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(3-{1-[6-(4-Chlorophenoxy)-6-phenylhexyl]-4-piperidinyl}phenyl)-2-methylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Chlorophenol | HCID 4684 | — |
| Reactant | N-(3-[1-(6-hydroxy-6-phenylhexyl)-4-piperidinyl]phenyl}-2-methylpropanamide | HCID 22049151 | — |
| Product | N-(3-{1-[6-(4-Chlorophenoxy)-6-phenylhexyl]-4-piperidinyl}phenyl)-2-methylpropanamide | HCID 22049460 | — |
Reaction Steps
Prepared by Procedure A and Scheme AN using 4-chlorophenol and N-{3-[1-(6-hydroxy-6-phenylhexyl)-4-piperidinyl]phenyl}-2-methylpropanamide: 1H NMR (400 MHz, CDCl3), HCl salt δ 8.28 (s, 1H), 7.78-6.70 (m, 13H), 5.08-4.98 (m, 1H), 3.64-3.46 (m, br, 2H), 3.02-2.82 (br, 2H), 2.82-2.56 (m, br, 4H), 2.56-2.34 (m, br, 2H), 2.05-1.75 (m, br, 6H), 1.64-1.48 (m, br, 1H), 1.48-1.34 (br, 3H), 1.25 (d, 6H, J=6.8 Hz); ESMS m/e: 533.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06727264B1 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-e8344ed72948474b866af4c05af26402 |
| Source note | uspto-grants-2004_04 |