HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(3-{1-[6-(4-Fluorophenoxy)-6-phenylhexyl]-4-piperidinyl}phenyl)-2-methylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Fluorophenol | HCID 9732 | — |
| Reactant | N-(3-[1-(6-hydroxy-6-phenylhexyl)-4-piperidinyl]phenyl}-2-methylpropanamide | HCID 22049151 | — |
| Product | N-(3-{1-[6-(4-Fluorophenoxy)-6-phenylhexyl]-4-piperidinyl}phenyl)-2-methylpropanamide | HCID 22048856 | — |
Reaction Steps
Prepared by Procedure A and Scheme AN using 4-fluorophenol and N-{3-[1-(6-hydroxy-6-phenylhexyl)-4-piperidinyl]phenyl}-2-methylpropanamide: 1H NMR (400 MHz, CDCl3), HCl salt δ 8.05 (s, br, 1H), 7.72-6.70 (m, 13H), 5.06-4.96 (m, 1H), 3.66-3.51 (m, 2H), 3.01-2.82 (m, br, 2H), 2.82-2.57 (m, br, 4H), 2.57-2.34 (m, br, 2H), 2.05-1.78 (m, br, 6H), 1.64-1.52 (m, br, 1H), 1.52-1.16 (m, br, 3H), 1.25 (d, 6H, J=7.2 Hz); ESMS m/e: 517.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06727264B1 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-730af72258b94e3b9fb10cc356545d83 |
| Source note | uspto-grants-2004_04 |