HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-[3-(1-{5-(3-Fluorophenyl)-5-[2-fluoro-5-(trifluoromethyl)phenoxy]pentyl}-4-piperidinyl)phenyl]-2-methylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Fluoro-5-(trifluoromethyl)phenol | HCID 518888 | — |
| Reactant | N-(3-{1-[5-(3-fluorophenyl)-5-hydroxypentyl)-4-piperidinyl}phenyl)-2-methylpropanamide | HCID 22048596 | — |
| Product | N-[3-(1-{5-(3-Fluorophenyl)-5-[2-fluoro-5-(trifluoromethyl)phenoxy]pentyl}-4-piperidinyl)phenyl]-2-methylpropanamide | HCID 22049095 | — |
Reaction Steps
Prepared by Procedure A and Scheme AN using 2-fluoro-5-(trifluoromethyl)phenol and N-(3-{1-[5-(3-fluorophenyl)-5-hydroxypentyl]-4-piperidinyl}phenyl)-2-methylpropanamide: 1H NMR (400 MHz, CDCl3), HCl salt δ 7.79 (s, br, 1H), 7.63-6.82 (m, 11H), 5.24-5.15 (m, 1H), 3.70-3.56 (br, 2H), 3.04-2.84 (br, 2H), 2.82-2.60 (m, br, 4H), 2.60-2.42 (m, br, 2H), 2.20-1.83 (m, br, 6H), 1.70-1.44 (m, br, 2H), 1.25 (d, 6H, J=6.4 Hz); ESMS m/e: 589.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06727264B1 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-86dd17ccac34441e8133b86a5f924b18 |
| Source note | uspto-grants-2004_04 |