Sodium borohydride → HCID 69891916, compound

Participants

Reaction Steps

Sodium borohydride (8.7 g, 0.23 mol) was added to a stirred suspension of (1R*,5S*,6R*)-8-benzyl-6-(tert-butoxycarbonyl)-1-phenyl-8-azabicyclo[3.2.1]octan-2-one (Description 19a; 76 g, 0.23 mol) in methanol (700 ml) at room temperature. The reaction mixture was stirred overnight, quenched with water and concentrated in vacuo. The residue was extracted into ethyl acetate. The combined organic extracts were dried (MgSO4) and concentrated in vacuo to give the title compound as a white solid.

Provenance & Evidence