Sodium Azide → (1R*,2R*,5R*)-8-(4-Azidobut-2-ynyl)-2-{[3,5-bis(trifluoromethyl)phenyl]-methoxy}-1-phenyl-8-azabicyclo[3.2.1]octane

Participants

Reaction Steps

(1R*,2R*,5R*)-2-{[3,5-Bis(trifluoromethyl)phenyl]methoxy}-8-(4-chlorobut-2-ynyl)-1-phenyl-8-azabicyclo[3.2.1]octane (Description 26; 254 mg, 0.49 mmol) and sodium azide (35 mg, 0.54 mmol) were stirred in dimethylformamide (3 ml) at room temperature overnight. The reaction mixture was diluted with water and the product extracted with ethyl acetate (×3), dried (MgSO4) and concentrated in vacuo to give the title compound as an orange oil.

Provenance & Evidence