Diethyl Ether → HCID 86586650, compound

Participants

Reaction Conditions

Reaction Steps

Dimethylbis(cyclopentadienyl)titanium (12 ml, 0.45M solution in toluene) was added to a solution of (1R*,2R*,5S*,6R*)-8-benzyl-2-[3,5-bis(trifluoromethyl)benzoyloxy]-6-(1-methyl-1H-tetrazol-5-yl)-1-phenyl-8-azabicyclo[3.2.1]octane (Description 33b; 0.83 g, 1.35 mmol) in toluene (20 ml). The mixture was stirred at 100° C. for 3 hours. On cooling to room temperature the mixture was poured into 100 ml of 1:1 diethyl ether:iso-hexanes. The mixture was filtered through Celite™and the filtrate concentrated in vacuo. The residue was chromatographed on silica gel eluting with 10, 20 and 50% ethyl acetate/iso-hexanes to yield the title compound (0.57 g, 69%).

Provenance & Evidence