Ethyl Acetate → HCID 69891696, compound

Participants

Reaction Steps

A mixture of (1R*,5S*,6S*)-8-benzyl-6-cyano-1-phenyl-8-azabicyclo[3.2.1]oct-3-en-2-one (Description 39b; 44 g, 140 mmol), 10% palladium on charcoal (11 g, 10 mmol), ethyl acetate (200 ml) was stirred under hydrogen atmosphere (1 atm) at room temperature for 1.5 hours. The reaction mixture was treated with dichloromethane (500 ml), filtered through a pad of Celite™. The Celite™ cake was well washed with dichloromethane to dissolve solid product. The filtrate was concentrated to give the title compound.

Provenance & Evidence