Hydrochloric Acid → HCID 69889711, compound

Participants

Reaction Steps

A mixture of (1R*,2R*,5S*,6S*)-8-benzyl-2-(tert-butyldimethylsilyloxy)-6-fluoro-6-[1-(2-methoxyethoxymethyl)-1H-tetrazol-5-yl]-1-phenyl-8-azabicyclo[3.2.1]octane (Description 44a; 4.5 g, 7.7 mmol), 1 M solution of hydrogen chloride in ether (30 ml) and methanol (50 ml) was stirred at room temperature for 90 minutes. The reaction mixture was treated with saturated aqueous NaHCO, and extracted into ethyl acetate. The combined organic extracts were dried (Na2SO4) and concentrated. The residue was purified by chromatography on silica gel (iso-hexane:diethyl ether 20-80%) to give the title compound (2.5 g, 70%).

Provenance & Evidence