Hydrochloric Acid → HCID 69685789, compound

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Reaction Steps

A mixture of (1S,2S,5S)-2-(tertbutyldimethylsilyloxy)-1-phenyl-8-(prop-2-enyl)-8-azabicyclo[3.2.1]octane (Description 56; 230 mg, 0.64 mmol), 2M hydrochloric acid (3 ml) and methanol (6 ml) was stirred at +55° C. over 5 days, then concentrated in vacuo and quenched with saturated aqueous NaHCO3. The mixture was extracted with dichloromethane. The combined organic extracts were dried (Na2SO4) and concentrated. The residue was purified by chromatography on silica gel (dichloromethane:methanol:ammonia) to give the title compound (116 mg, 74%).

Provenance & Evidence