HCID 9961266, compound → HCID 86759432, compound

Participants

Reaction Steps

A mixture of (1R*,2R*,5S*,6R*)-8S*)-8-benzyl-2-[3,5-bis(trifluoromethyl)-phenylmethoxy]-1-phenyl-6-phenylsulphonyl-8-azabicyclo[3.2.1]octane (Example 1; 450 mg, 0.68 mmol), 5% palladium on charcoal (1 g, 0.47 mmol) and ethanol (20 ml) was stirred under hydrogen atmosphere (1 atm) at +65° C. for 8 hours. The reaction mixture was cooled to room temperature, flushed with nitrogen gas and filtered through a pad of Celite™. The filtrate was concentrated and purified by flash chromatography to give the title compound (233 mg, 60%). The hydrochloride salt of the title compound was prepared by treatment with ethereal HCl.

Provenance & Evidence