HCID 86586642, compound → HCID 86586654, compound

Participants

Reaction Steps

A mixture of (1R*,2S*,5S*,6R*)-8-benzyl-2-{[3,5-bis(trifluoromethyl)phenyl]methoxy}-1-phenyl-6-phenylsulphonyl-8-azabicyclo[3.2.1]oct-3-ene (Description 6; 390 g, 0.59mol), 10% palladium on charcoal (473 mg) and ethanol (25 ml) was stirred under hydrogen atmosphere (1 atm) at +70° C. for 2 hours and at room temperature overnight. The reaction mixture was cooled to room temperature, flushed with nitrogen gas and filtered through a pad of Celite™. The filtrate was concentrated and purified by flash chromatography to give the title compound (250 mg, 74%). The hydrochloride salt of the title compound was prepared by treatment with ethereal HCl and recrystallized from dichloromethane-ether.

Provenance & Evidence