Water → (1R*,2R*,5R*)-2-{[3,5-Bis(trifluoromethyl)phenyl]methoxy}-1-(4-fluorophenyl)-8-[(1-methyl-1,2,4-triazol-3-yl)methyl]-8-azabicyclo[3.2.1]octane hydrochloride

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Reaction Conditions

Reaction Steps

(1R*,2R*,5R*)-2-{[3,5-Bis(trifluoromethyl)phenyl]methoxy}-1-(4-fluorophenyl)-8-azabicyclo[3.2.1]octane (Example 18; 101 mg, 0.23 mmol), potassium carbonate (159 mg, 1.15 mmol), and 1-methyl-3-chloromethyl-1,2,4 triazole (386 mg, 2.30 mmol) were combined in dimethylformamide and heated at 80° C. for 5 days. The reaction mixture was poured into water and extracted with ethyl acetate (×3), dried (MgSO4) and concentrated in vacuo to give a yellow oil. This was purified by flash column chromatography [7.5% methanol in dichloromethane] to give desired product. The hydrochloride salt was made by adding 1 equivalent of 1N hydrogen chloride in diethyl ether to a solution in diethyl ether. The salt was further purified by SCX cartridge eluting with methanol then ammonia in methanol. The ammonia washings were collected and concentrated in vacuo and the hydrochloride salt made by adding 1 equivalent of 1N hydrogen chloride in diethyl ether to a solution in-diethyl ether. The solid formed was filtered and dried at 60° C. in vacuo to give the title compound.

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