Ethyl Acetate → HCID 86586662, compound

Participants

Reaction Steps

A mixture of (1R*,2R*,5S*,6S*)-8-benzyl-2-{[3,5-bis(trifluoromethyl)phenyl]methoxy}-6-(tert-butoxycarbonyl)-1-phenyl-8-azabicyclo[3.2.1]octane (Description 22; 826 mg, 1.33 mmol), 10% palladium on charcoal (470 mg, 0.44 mmol), ethyl acetate (10 ml) and ethanol (10 ml) was stirred under hydrogen atmosphere (1 atm) at +60° C. for 1 hour. The reaction mixture was cooled to room temperature, flushed with nitrogen gas and filtered through a pad of Celite™. The filtrate was concentrated to give the title compound (500 g, 71%).

Provenance & Evidence