Sodium Hydroxide → HCID 86586688, compound

Participants

Reaction Conditions

Reaction Steps

Tetrakis(triphenylphosphine)palladium(0) (64 mg, 0.055 mmol) was added to a stirred mixture of (1R*,2R*,5S*,6R*)-2-{[3,5-bis(trifluoromethyl)phenyl]methoxy}-6-cyano-1-phenyl-8-(prop-2-enyl)-8-azabicyclo[3.2.1]octane (Example 55; 500 mg, 1.01 mmol), 1,3-dimethylbarbituric acid (465 mg, 3.0 mmol) in dichloromethane (10 ml) at room temperature. The reaction mixture was stirred at 30-35° C. for 90 minutes and treated with 2M aqueous NaOH (10 ml). The mixture was stirred for 5 minutes, then diluted with water (30 ml) and extracted into dichloromethane. The combined organic extracts were dried (Na2SO4) and concentrated. The residue was purified by chromatography on silica gel (iso-hexane:ethyl acetate 10-40%) to give the title compound (392 mg, 85%). The hydrochloride salt of the title compound was prepared by treatment with ethereal HCl.

Provenance & Evidence