Hydrochloric Acid → HCID 86586705, compound

Participants

Reaction Steps

A solution of (1R*,2R*,5S*,6R*)-8-Benzyl-2-{[3,5-bis(trifluoromethyl)phenyl]-methoxy}-6-[4-methylthioazol-2-yl]-1-phenyl-8-azabicyclo[3.2.1]octane (Example 78; 50 mg, 0.081 mmol) in diethyl ether (2 ml) was treated 1M etheral HCl (0.3 ml). The mixture was concentrated in vacuo. The residue was treated with 10% palladium on charcoal (180 mg) ethanol (10 ml) was stirred under hydrogen atmosphere (1 atm) at +65° C. for 30 minutes. The reaction mixture was cooled to room temperature, flushed with nitrogen gas and filtered through a pad of Celite™. The filtrate was concentrated and purified by preparative TLC (dichloromethane:methanol) to give the title compound (15 mg, 35%). The hydrochloride salt of the title compound was prepared by treatment with ethereal HCl.

Provenance & Evidence