Potassium Carbonate → HCID 86586716, compound

Participants

Reaction Steps

(1R*,2R*,5S*,6R*)-2-{(3,5-Bis(trifluoromethyl)phenyl]methoxy}-6-formyl-1-phenyl-8-azabicyclo[3.2.1]octane (Example 47; 165 mg, 0.3 mmol) in methanol (3 ml) at 0° C. was treated with potassium carbonate (83 mg, 0.6 mmol) and dimethyl 1-diazo-2-oxopropylphosphonate (81 mg, 0.5 mmol) and stirred for 18 hours at room temperature. The reaction mixture was concentrated in vacuo. The residue was partitioned between water and hexane. The organics were collected, dried (MgSO4), filtered and concentrated in vacuo to afford the title compound as a white crystalline solid (123 mg, 75%).

Provenance & Evidence