反应详情

(1R*,2R*,5S*,6R*)-8-Benzyl-2-{(1R*)-1-[3,5-bis(trifluoromethyl)phenyl]-(methoxycarbonyl)methoxy}-6-cyano-1-phenyl-8-azabicyclo[3.2.1]octane (Example 155; 2.408 g, 4 mmol) in methanol (25 ml) was treated with sodium borohydride (2.2698 g, 0.60 mmol) potionwise at 5-10° C. The reaction was quenched with acetone and concentrated in vacuo. The residue was partitioned between ethyl acetate and water, the organics separated and dried (MgSO4) and concentrated in vacuo to afford the title compound as a white foam in quantitative yield.

1. customThe reaction was quenched with acetone
2. concentrationconcentrated in vacuo
3. customThe residue was partitioned between ethyl acetate and water
4. customthe organics separated
5. dry with materialdried (MgSO4)
6. concentrationconcentrated in vacuo