HCID 86586785, compound → HCID 86586786, compound

Participants

Reaction Steps

(1R*,2R*,5S*,6R*)-8-Benzyl-2-{(1R*)-1-[3,5-bis(trifluoromethyl)phenyl]-2-methoxyethoxy}-6-(2-methyl-1H-tetrazol-5-yl)-1-phenyl-8-azabicyclo[3.2.1]octane (Example 200; 0.03 g, 0.05 mmol), palladium, 5% on carbon (20 mg) and acetic acid (0.5 ml) were placed on the Parr™ apparatus for 2 hours. The mixture was filtered using a Whatman™ 0.2·m filter and concentrated in vacuo. The residue was taken into dichloromethane and washed with NaHCO3 and the phases separated using a bond elute cartridge. The organics were concentrated in vacuo and the title compound isolated as the hydrochloride salt.

Provenance & Evidence