Glycine → N-Phthaloylglycine

HRID 2088253Notes

Reaction equation

[NH2:1][CH2:2][C:3]([OH:5])=[O:4].[C:6]1(=O)[O:11][C:9](=[O:10])[C:8]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:7]12>>[O:10]=[C:9]1[C:8]2[C:7](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:6](=[O:11])[N:1]1[CH2:2][C:3]([OH:5])=[O:4]

Participants

Reactant 2

HCID 750Glycine

HCID 6811Phthalic Anhydride

Product 1

HCID 20825N-Phthaloylglycine

Procedure

(G1) irradiating a reaction product of glycine (a) and phthalic anhydride (b) with microwaves to produce 2-(1,3-dioxoisoindolin-2-yl)acetic acid (compound 1);

Sources & evidence

ORD record: ord-c045b887ee4946fb8b24646593932ae8
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08435480B2

Reaction notes

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