Glycine → N-Phthaloylglycine

HRID 2088255Notes

Reaction equation

HRID 2088255 reaction equation
[NH2:1][CH2:2][C:3]([OH:5])=[O:4].[C:6]1(=O)[O:11][C:9](=[O:10])[C:8]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:7]12>>[O:10]=[C:9]1[C:8]2[C:7](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:6](=[O:11])[N:1]1[CH2:2][C:3]([OH:5])=[O:4]

Participants

3

Reactant 2

HCID 750Glycine2×HCID 6811Phthalic Anhydride3×

Product 1

HCID 20825N-Phthaloylglycine

Procedure

In the present invention, the (G1) step is a step to produce 2-(1,3-dioxoisoindolin-2-yl)acetic acid (compound 1) by irradiating a reaction product of glycine (compound a) and phthalic anhydride (compound b) with microwaves. In this step, glycine and phthalic anhydride undergo the co-condensation reaction to produce the compound 1. Here, water is added in a small amount to prevent overheating, so that the compound 1 to be produced is not be burned.

Workup

  1. customthe co-condensation reaction

Sources & evidence

ORD record
ord-0c30eb85d64b4b9c877ee32eb531bf6c
Source dataset
uspto-grants-2013_05
Patent number
US08435480B2

Reaction notes

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