反应详情

温度

25 °C

13.74 g of sodium cyanide are dissolved in 200 ml of water. Over a period of 30 min, 50 g of 4-trifluoroethoxycyclohexanone are then added dropwise at 20-28° C. with slight cooling. The mixture is stirred at 25° C. for 5 minutes, and 31.48 g of sodium disulfite, dissolved in 100 ml of water, are then added dropwise with cooling at 25-30° C. over a period of 30 min. With monitoring by thin-layer chromatography, the mixture is stirred at room temperature. The aqueous phase is extracted 3× with in each case 90 ml of toluene. The organic phases are combined and concentrated under reduced pressure.

1. additionare then added dropwise
2. temperaturewith cooling at 25-30° C. over a period of 30 min
3. stirringthe mixture is stirred at room temperature
4. extractionThe aqueous phase is extracted 3× with in each case 90 ml of toluene
5. concentrationconcentrated under reduced pressure