Triethylamine → WS-070117

Participants

Reaction Conditions

Reaction Steps

To a solution of O2′,O3′,O5′-tri-acetyl-6-chloroadenosine (5.4 g) in absolute ethanol (30 mL) were added 3-aminophenol (4.28 g) and dry triethylamine (3.96 g), and the mixture was refluxed 8 h at 60° C. The solution was allowed to cool and was concentrated in vacuo and the residue was chromatographed (ethyl acetate:petroleumether=2:1) to give O2′,O3′,O5′-tri-acetyl-N6-(3-hydroxylphenyl)adenosine as a white solid (1.51 g).

Provenance & Evidence