Benzoic Acid → HCID 86647592, compound

Participants

Reaction Steps

17-Oximino-5-androsten-3β-ol (9) (0.5 g, 1.6 mmol) and dicyclohexylcarbodiimide (DCC) (0.34 g, 1.6 mmol) was dissolved in anhydrous dichloromethane (30.0 ml) and stirred. To this was added benzoic acid (0.2 g, 1.6 mmol). The reaction mixture was stirred for 48 hr at room temperature (20-25°) and completion of the reaction was monitored by TLC. The precipitated material was filtered, solvent removed under reduced pressure to give residue which was crystallized from ethyl acetate:petroleum ether (60:80) to get 17-oximino-5-androsten-3β-yl benzoate (13) (0.32 g, 64.0%) mp 165-170° C.

Provenance & Evidence