4-(Piperidin-1-yl)pyridin-3-amine → 5-amino-2-(2,6-difluorophenyl)-N-(4-(piperidin-1-yl)pyridin-3-yl)thiazole-4-carboxamide

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Reaction Steps

Following the procedures as described in EXAMPLE 1 and starting with 4-(piperidin-1-yl)pyridin-3-amine and 5-(tert-butoxycarbonylamino)-2-(2,6-difluorophenyl)thiazole-4-carboxylic acid, the title compound was obtained as a white solid (36 mg, 34%). 1H NMR (400 MHz, DMSO) δ 9.40 (s, 1H), 9.35 (s, 1H), 8.21 (d, J=5.2, 1H), 7.67 (s, 2H), 7.53 (tt, J=8.3, 6.3, 1H), 7.29 (p, J=2.6, 2H), 7.13 (d, J=5.3, 1H), 2.90-2.80 (m, 4H), 1.76-1.64 (m, 4H), 1.51 (d, J=5.3, 2H). ESIMS m/z=416.1 (M+1).

Provenance & Evidence